Recent Publication:

Novel Pharmaceutical Cocrystals and Salts of Bumetanide

New crystalline forms of bumetanide, namely four cocrystals, two salts and one salt-cocrystal were crystallized. Urea and lactams such as valerolactam, caprolactam, N-methyl caprolactam formed cocrystals with bumetanide whereas 4-aminopyridine gave a salt. Piperazine afforded a salt hydrate and 5-flurocytosine gave a salt-cocrystal. The supramolecular synthons in bumetanide-lactam cocrystals are amide dimer between drug and coformer, and acid homo dimer between bumetanide molecules. In bumetanide salts, the acid proton is transferred from bumetanide to coformer amine whereas in bumetanide salt-cocrystal proton transfer and free acid was observed in the crystal structure. Similar to the cytosine salt-cocrystal of bumetande, fluorocytosine also gave salt-cocrystal adduct. The acid proton of bumetanide is transferred to 2-amino pyridine base of cytosine as a salt, and on the other side of drug molecule the sulfonamide interacts with the syn amide part of cytosine. Furthermore, solubility, dissolution and diffusion membrane permeability experiments were performed on all new solid forms. Piperazine salt shows high dissolution and permeability cross-over when compared to other binary forms of bumetanide.

Authors:  Suryanarayana Allu, Geetha Bolla, Srinu Tothadi, Ashwini K Nangia*

 Publication date : Dec 16th, 2019




Recent Announcements

  • Prof. Nangia Started A gold Medal in the memory of Late Mrs. Uma Devaguptapu for the Women Topper in MBA at University of Hyderabad A Medal in the memory of Late Mrs. Uma Devaguptapuhas been instituted for the Women Topper in MBA General Course at the School of Management Studies @HydUniv. Late Mrs. Uma Devaguptapu was associated with Signode as its Director –HR. @OfficeOfSDhotre @HRDMinistry @PIB_Indiahttps://twitter.com/HydUniv/status/1223207261230653440?s=20
    Posted Jan 31, 2020, 4:17 AM by Ashwini Nangia
  • TB-Drug-Breakthrough-Happens-at-CSIR-NCL TB-Drug-Breakthrough-Happens-at-CSIR-NCLCSIR- National Chemical Laboratory (CSIR-NCL), Pune has come up with an Anti-TB cocrystal drug having improved stability. The research work by Prof A K Nangia and the team at the CSIR-NCL and the School of Chemistry, University of Hyderabad has cleared the way for the development of a stable formulation of 4-FDC (4 drugs fixed-dose combination) for TB.A study by Prof Nangia led team has reported a new cocrystal of FDC of TB drug to address these issues in the Journal of Pharmaceutical Sciences. The team including Suryanarayana Cherukuvada, Devarapaga Maddileti, Swapna Battini, and M K Chaitanya Mannava, studied the cause for the instability of the four ...
    Posted May 3, 2018, 7:28 PM by Ashwini Nangia
  • Section editor of Acta Crystallographica Section B Wrriten by Prof. Desiraju: It's a pleasure to record the appointment of Prof. Ashwini Kumar Nangia, Director, National Chemical Laboratory, Pune as a main editor of Acta Crystallographica Section B. Prof. Nangia heads one of the largest labs in the CSIR family and brings a great deal of experience in crystallography, crystal engineering and organic chemistry. He is very well known within IUCr and is also a member of its Commission on Structural Chemistry. Acta Cryst B is rapidly growing in stature and impact. I recollect that one of my own papers (1989) in this journal was a personal turning point for me. Acta B is a journal by the experts, for the experts and of the experts. with ...
    Posted May 19, 2017, 3:18 AM by Ashwini Nangia
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