Ashwini Nangia Research Group



Recent Publication:


Mechanochemical synthesis of N-salicylidene-aniline: thermosalient effect of polymorphic crystals

Polymorphs of the dichloro derivative of N-salicylideneaniline exhibit mechanical responses such as jumping (Forms I and III) and exploding (Form II) in its three polymorphs. The molecules are connected via the amide N—HO dimer synthon and C—ClO halogen bond in the three crystal structures. A fourth high-temperature Form IV was confirmed by variable-temperature single-crystal X-ray diffraction at 180C. The behaviour of jumping exhibited by the polymorphic crystals of Forms I and III is due to the layered sheet morphology and the transmission of thermal stress in a single direction, compared with the corrugated sheet structure of Form II such that heat dissipation is more isotropic causing blasting. The role of weak C—ClO interactions in the thermal response of molecular crystals is discussed.

Publication date : March 13th, 2017


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  • Twenty-Fourth Congress and General Assembly of the International Union of Crystallography India will host the 24th Congress & General Assembly of the International Union of Crystallography 2017 from 21 – 28 August 2017. We extend a warm welcome to all crystallographers from across ...
    Posted Sep 8, 2016, 5:11 PM by Ashwini Nangia
  • FDA to Reclassify Pharmaceutical Co-Crystals As part of an effort to clarify and help advance the development of pharmaceutical co-crystals, the US Food and Drug Administration (FDA) on Tuesday released revised draft guidance providing ...
    Posted Sep 8, 2016, 3:08 AM by Ashwini Nangia
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