Prof. Ashwini Nangia's Research Group


Recent Publication:

Pefloxacin (PEF) is an amphoteric, antibacterial drug which exists as a neutral molecule in the crystal structure stabilized by C–H···O and C–H···F interactions. The design of multicomponent solids using crystal engineering was undertaken in a cocrystal / salt screen of PEF with GRAS dicarboxylic acids to improve the solubility and phase stability of the drug. Ten multicomponent forms, namely five salts, two salt hydrates, and three salt-cocrystals were crystallized by liquidassisted grinding followed by crystallization. In some cases, salt and salt-cocrystals were obtained concomitantly during solution evaporative crystallization. Single crystal X-ray diffraction showed that the structures are stabilized by N+ –H···O , O–H···O, C–H···O, C–H···F and π- π stacking interactions. The bulk phase purity of multicomponent forms was characterized by powder X-ray diffraction, spectroscopy and thermal techniques. The salt /salt-cocrystal forms exhibit faster dissolution rate and higher solubility compared to pure PEF in pH 1.2 (acidic, like gastric environment) and pH 7 phosphate buffer media (neutral, like intestinal passage). Specifically, PEF+ -SA– salt showed remarkably high solubility, dissolution rate and stability compared to the other multicomponent forms and PEF neutral form. The drug formulation compatible pefloxacin succinate is a promising soluble and stable PEF salt.

Authors: Anilkumar GunnamKuthuru Suresh, and Ashwini Nangia*

1School of Chemistry, University of Hyderabad, Hyderabad 500 046, India

2Council of Scientific and Industrial Research National Chemical Laboratory, Pune       411 008, India

 *Correspondence e-mail: ashwini.nangia@gmail.com

                                                          

 Publication date : March 26th, 2018





Recent Announcements

  • TB-Drug-Breakthrough-Happens-at-CSIR-NCL TB-Drug-Breakthrough-Happens-at-CSIR-NCLCSIR- National Chemical Laboratory (CSIR-NCL), Pune has come up with an Anti-TB cocrystal drug having improved stability. The research work by ...
    Posted May 3, 2018, 7:28 PM by Ashwini Nangia
  • Section editor of Acta Crystallographica Section B Wrriten by Prof. Desiraju: It's a pleasure to record the appointment of Prof. Ashwini Kumar Nangia, Director, National Chemical Laboratory, Pune as a main editor of Acta Crystallographica Section ...
    Posted May 19, 2017, 3:18 AM by Ashwini Nangia
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