Prof. Ashwini Nangia's Research Group

Recent Publication:

Cocrystallization of the anti-diabetic drug Eparlestat (EPR) with cytosine (CYT) gave EPR CYT-H+ form I, a salt-cocrystal hybrid structure, salt hydrate (EPR CYT-H+ H2O, 1:2:1), and non-stoichiometric solvates of EPR CYT-H+ with EtOH/n-PrOH included in the rhombohedral symmetry voids, referred to as form II. Desolvation of EPR CYT-H+ form II solvates resulted in an unsolvated form II of EPR CYT-H+ which was characterized by DSC, TGA and NMR. The carboxylate···cytosinium synthon was observed in the salts structure along with the uncommon CYT-H+ ···H+ -CYT base pairing in the structures of saltcocrystal hybrid and salt hydrate. The crystalline forms were characterized by spectroscopic (IR, NMR), thermal (DSC, HSM, TGA), powder X-ray diffraction (PXRD) and single crystal X-ray diffraction (SC-XRD) techniques. The intent of using the salt/ salt-cocrystal forms as a means to stop the E,Z Z,Z isomerization of EPR was not successful in photo-irradiation experiments.

Publication date : May 10th, 2017





Recent Announcements

  • Section editor of Acta Crystallographica Section B Wrriten by Prof. Desiraju: It's a pleasure to record the appointment of Prof. Ashwini Kumar Nangia, Director, National Chemical Laboratory, Pune as a main editor of Acta Crystallographica Section ...
    Posted May 19, 2017, 3:18 AM by Ashwini Nangia
  • Twenty-Fourth Congress and General Assembly of the International Union of Crystallography India will host the 24th Congress & General Assembly of the International Union of Crystallography 2017 from 21 – 28 August 2017. We extend a warm welcome to all crystallographers from across ...
    Posted Sep 8, 2016, 5:11 PM by Ashwini Nangia
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