Prof. Ashwini Nangia's Research Group


Recent Publication:

Curcumin is a natural compound present in Indian spice turmeric. It has diverse pharmacological action but low oral solubility and bioavailability continue to limit its use as a drug. With the aim of improving the bioavailability of Curcumin (CUR), we evaluated Curcumin-Pyrogallol (CUR-PYR) cocrystal and Curcumin-Artemisinin (CUR-ART) coamorphous solid. Both of these solid forms exhibited superior dissolution and pharmacokinetic behavior compared to pure CUR, which is practically insoluble in water. CUR-ART coamorphous solid showed two fold higher bioavailability than CUR-PYR cocrystal (at 200 mg/kg oral dose). Moreover, in simulated gastric and intestinal fluids (SGF and SIF), CUR-ART is stable up to 3 and 12 h, respectively. In addition, CUR-PYR and CUR-ART showed no adverse effects in toxicology studies (10 times higher dose at 2000 mg/kg). CUR-ART showed higher therapeutic effect and inhibited approximately 62% of tumor growth at 100 mg/kg oral dosage of CUR in xenograft models, which is equal to the positive control drug, doxorubicin (2 mg/kg) by i.v. administration.

Authors: M. K. Chaitanya Mannava 1,2, Kuthuru Suresh 1,2, Manish Kumar Bommaka 1, Durga Bhavani Konga 3 and Ashwini Nangia 1,2,4,*

1School of Chemistry, University of Hyderabad, Hyderabad 500 046, India

2Technology Business Incubator, University of Hyderabad, Hyderabad 500 046, India

3Virchow Biotech Pvt. Ltd., Animal House Facility, Hyderabad 500 055, India

4Council of Scientific and Industrial Research National Chemical Laboratory, Pune       411 008, India

 *Correspondence e-mail: ashwini.nangia@gmail.com

                                                          

 Publication date : January 9th, 2018

http://www.mdpi.com/journal/pharmaceutics
http://www.mdpi.com/


Recent Announcements

  • Section editor of Acta Crystallographica Section B Wrriten by Prof. Desiraju: It's a pleasure to record the appointment of Prof. Ashwini Kumar Nangia, Director, National Chemical Laboratory, Pune as a main editor of Acta Crystallographica Section ...
    Posted May 19, 2017, 3:18 AM by Ashwini Nangia
  • Twenty-Fourth Congress and General Assembly of the International Union of Crystallography India will host the 24th Congress & General Assembly of the International Union of Crystallography 2017 from 21 – 28 August 2017. We extend a warm welcome to all crystallographers from across ...
    Posted Sep 8, 2016, 5:11 PM by Ashwini Nangia
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