Research News


posted Nov 2, 2020, 9:25 PM by Ashwini Nangia   [ updated Nov 2, 2020, 9:50 PM ]

Based on data compiled and studied by John Loannidis of Stanford University, Elsevier and SciTech Strategies, and published in the highly respected journal PLOS Biology last week, three UoH faculty figure in the global top 200 researchers in their respective fields: MNV Prasad, of the School of Life Sciences is ranked 116th in the field of Environmental Sciences, Ashwini Nangia of the School of Chemistry, ranked 124th in the field of Inorganic and Nuclear Chemistry, and Pramod K Nayar of the Department of English ranked 189th, in the field of Literary Studies. 


              Ashwini Nangia                  Pramod K Nayar                      MNV Prasad

UoH also has a spectacular presence in this dataset of “Subject-wise ranking of top 2% Scientists from India (all fields)” from the published paper. In addition to the above three, here is the list of UoH’s super-achievers from authors indexed in the Stanford project’s findings:


S.N. Kaul : Applied Physics                             Alok Singh : Artificial Intelligence & Image Processing




Vineet Nair : Artificial Intelligence &                              Ashok Chatterjee: General Physics

Image Processing



D. Basavaiah : Organic Chemistry                               K.D. Sen : Chemical Physics




Periasamy : Organic Chemistry                                       Anunay Samanta: Chemical Physics



Samudranil Pal : Inorganic and                                           Venugopal Rao : Optoelectronics & Photonics

Nuclear Chemistry



Narayana Rao : Optoelectronics & Photonics              Goverdhan Mehta : Organic Chemistry


             A.S. Raghavendra : Plant Biology and Botany

The paper’s data also shows the citation percentage for the above faculty, based on SCOPUS databased publications.

UoH clearly demonstrates excellence across multiple disciplines as can be seen from this data, with concentrations of high-impact work in Computer & Information Sciences, Physics, Chemistry, Life Sciences and English (in the last instance, UoH boasts the only Indian academic (Pramod K Nayar)in the world’s top 200).

UoH congratulates our faculty for bringing laurels to the University.

Several former UoH Faculty, such as ED Jemmis and Gautam Desiraju, are also on this list of fabulous researchers.

Prof Appa Rao Podile, Vice Chancellor, greeted the faculty for their wonderful achievements in research and publications. He said:  “we are performing extremely well in research across several disciplines, as proved yet again by this study in PLOS Biology. I believe that these outstanding researchers will inspire others and our overall performance will improve rapidly.

We are also proud of distinguished former faculty who retain their regard and affection for UoH”.


Prof. Nangia Started A gold Medal in the memory of Late Mrs. Uma Devaguptapu for the Women Topper in MBA at University of Hyderabad

posted Jan 31, 2020, 3:43 AM by Ashwini Nangia   [ updated Jan 31, 2020, 4:17 AM ]

A Medal in the memory of Late Mrs. Uma Devaguptapu
has been instituted for the Women Topper in MBA General Course at the School of Management Studies
. Late Mrs. Uma Devaguptapu was associated with Signode as its Director –HR.


posted May 3, 2018, 7:28 PM by Ashwini Nangia


CSIR- National Chemical Laboratory (CSIR-NCL), Pune has come up with an Anti-TB cocrystal drug having improved stability. The research work by Prof A K Nangia and the team at the CSIR-NCL and the School of Chemistry, University of Hyderabad has cleared the way for the development of a stable formulation of 4-FDC (4 drugs fixed-dose combination) for TB.

A study by Prof Nangia led team has reported a new cocrystal of FDC of TB drug to address these issues in the Journal of Pharmaceutical Sciences. The team including Suryanarayana Cherukuvada, Devarapaga Maddileti, Swapna Battini, and M K Chaitanya Mannava, studied the cause for the instability of the four-FDC drug chemical structures and discovered pharmaceutically stable cocrystal by applying Crystal Engineering principles to improve the stability, so that the drug inhibits the cross-reaction between Isoniazid and Rifampicin, and thereby overcomes the formation of inactive by-products. The pharmaceutical cocrystals of INH (INH-Caffeic acid and INH-Vanillic acid) were used to improve the stability of 4-drug FDC. The team showed that the pharmaceutically stable cocrystal of INH is able to improve the stability greater than 5-fold compared to the current 4-FDC drugs. The coformer additives which stabilise the formulation are pharmaceutically accepted excipients. Stability studies were carried out under accelerated conditions of 40°C temperature and 75 per cent relative humidity. The first time improvement of stability of anti-TB 4-FDC drugs using cocrystals of INH in a fixed dose formulation was reported. Tuberculosis (TB) is an airborne infectious disease caused by a species of pathogenic bacteria Mycobacterium Tuberculosis. It is one of the top ten leading causes of death worldwide.

According to the World Health Organisation (WHO), in 2015, an estimated 10.4 million people developed TB and 1.8 million died from the disease including 0.4 million deaths among HIV-positive people.

WHO has recommended Rifampicin (RIF), Isoniazid (INH), Pyrazinamide (PZA), and Ethambutol dihydrochloride (EDH) drugs for the treatment of TB. The use of a fixed-dose combination (2-drug, 3-drug and 4-drug FDCs) for the treatment for tuberculosis was recommended in 1994 by WHO and International Union against Tuberculosis and Lung Disease (IUATLD). In 1999 the 4-drug FDC tablet was included in the WHO Model List of Essential Drugs that comprises these four drugs. The 4-FDC tablets had quality and stability issues, including poor bioavailability of rifampicin and instability during storage; this raised serious concerns on the utility of this FDC. It was essential to address the quality and stability issues.

In March 2018, a summit intended to review the progress of efforts to eradicate TB took place in Delhi named the END TB Summit 2018. On the occasion, prime minister of India called for “greater focus on financing and political will to end TB by 2030”. He stressed that all forces must come together from private and public sectors and the civil society to fight this battle. All must join hands to overcome TB. The key components to combat TB are confirmative diagnosis, early initiation of Anti TB treatment and preventing the development of multi drug resistance. “Research & Development” is a key partner component on the battle against TB.

It was stated that Inventions of Anti-TB- Drugs and improvement of Drug quality are the major areas to explore.

Prof Nangia said, “Stable cocrystal drug with longer shelf life will improve the prospects of transport logistics and inventory management of TB drugs”. In the next phase, longer-term stability data on 4-FDC will be validated with suitable excipients and polymeric additives to develop the tablet formulation in fast-track translation.

Section editor of Acta Crystallographica Section B

posted May 19, 2017, 3:06 AM by Ashwini Nangia   [ updated May 19, 2017, 3:18 AM ]

Wrriten by Prof. Desiraju: It's a pleasure to record the appointment of Prof. Ashwini Kumar Nangia, Director, National Chemical Laboratory, Pune as a main editor of Acta Crystallographica Section B. Prof. Nangia heads one of the largest labs in the CSIR family and brings a great deal of experience in crystallography, crystal engineering and organic chemistry. He is very well known within IUCr and is also a member of its Commission on Structural Chemistry. Acta Cryst B is rapidly growing in stature and impact. I recollect that one of my own papers (1989) in this journal was a personal turning point for me. Acta B is a journal by the experts, for the experts and of the experts. with Prof. C. Malla Reddy of IISER Kolkata, who is a section editor of the same journal, I hope that many good papers in India (quality and quantity both required) start showing up in this important journal of structural chemistry and crystal engineering. My best wishes to both these talented chemists.

Twenty-Fourth Congress and General Assembly of the International Union of Crystallography

posted Oct 19, 2009, 10:41 PM by Ashwini Nangia   [ updated Sep 8, 2016, 5:11 PM ]

India will host the 24th Congress & General Assembly of the International Union of Crystallography 2017 from 21 – 28 August 2017. We extend a warm welcome to all crystallographers from across the world!

A cutting edge program with plenaries, keynotes, microsymposia and posters, commercial exhibits, satellite meetings, workshops and official meetings of the IUCr is planned. This will be a state of the art international meeting set in the unique ambience of India.

Hyderabad is a modern city of 9 million people that has gained prominence as an important software and pharmaceutical centre. Its iconic symbol is the Charminar or four minarets, which draws its inspiration from the tetragonal crystal system. It is the central motif in our logo for IUCr 2017.

Hyderabad International Airport has a wide range of connections through hubs in the Gulf, South East Asia and Europe. Of course, one can also fly in through Delhi, Mumbai or just about any major airport in India. The Congress venue, Hyderabad International Convention Centre (HICC) is on par with the best Congress destinations around the world and equipped with the finest technological, communication, digital and audio-visual tools.

We are sure that IUCr 2017 will be an experience to remember for everyone.

FDA to Reclassify Pharmaceutical Co-Crystals

posted Oct 19, 2009, 9:47 PM by Ashwini Nangia   [ updated Sep 8, 2016, 3:08 AM ]

As part of an effort to clarify and help advance the development of pharmaceutical co-crystals, the US Food and Drug Administration (FDA) on Tuesday released revised draft guidance providing information on the appropriate classification of co-crystal solid-state forms, the data that should be submitted to support the classification and the regulatory implications of such a classification.

“Co-crystals are crystalline materials composed of two or more different molecules, typically drug and co-crystal formers (‘coformers’), in the same crystal lattice. Pharmaceutical co-crystals have opened up opportunities for engineering solid-state forms beyond conventional solid-state forms of an active pharmaceutical ingredient (API), such as salts and polymorphs,” FDA explains. “Co-crystals can be tailored to enhance drug product bioavailability and stability and to enhance the processability of APIs during drug product manufacture. Another advantage of co-crystals is that they generate a diverse array of solid-state forms for APIs that lack ionizable functional groups, which is a prerequisite for salt formation.”

The new draft revises a previous guidance for industry, "Regulatory Classification of Pharmaceutical Co-Crystals" issued in April 2013, which classifies co-crystals as a drug product intermediate (or as an in-process material).

“This classification has contributed to uncertainty regarding the interpretation of the guidance because in a commercial setting, co-crystals are typically manufactured in drug substance facilities, yet when classified as a drug product intermediate, additional current good manufacturing practice requirements apply,” FDA says. “Therefore, the guidance has not been conducive to the development of co-crystals. In response to this and other feedback from stakeholders, FDA has reconsidered the appropriate classification of co-crystals.”


The short guidance also explains that co-crystals differ from salts and polymorphs, and are more similar to solvates, “in that both contain more than one component in the lattice. From a physical chemistry perspective, co-crystals can be viewed as a special case of solvates and hydrates, wherein the second component, the coformer, is nonvolatile. Therefore, co-crystals are classified as a special case of solvates in which the second component is nonvolatile.

“For NDAs and ANDAs containing or claiming to contain a co-crystal form, applicants should submit appropriate data that support the following:

  • If both drug and coformer have ionizable functional groups, a conclusion that the component drug and coformer exist in their neutral states in the co-crystal and interact nonionically. Consider the following to guide your decision: Generally speaking, if the API and its coformer have a ΔpKa (pKa (base) - pKa (acid)) > 1, there will be substantial proton transfer resulting in ionization and potential formation of a salt as opposed to a co-crystal. On the other hand, if the API and its coformer have a ΔpKa (pKa (base) - pKa (acid)) < 1, there will be less than substantial proton transfer. If this criterion is met, the API-coformer entity should be classified as a co-crystal. If, however, you believe that the classification of the pharmaceutical solid as a salt or co-crystal is not predicated on these relative pKa values, use spectroscopic tools and other orthogonal approaches to provide evidence to the contrary.
  • Assurance that substantial dissociation of the API from its co-crystal form occurs before reaching the site of pharmacological activity. Given that the interaction of the API with its coformer is of similar magnitude to the interaction of the API with solvents in solvates, an in vitro evaluation based on dissolution and/or solubility is generally considered sufficient to demonstrate that the active API dissociates from its coformer before reaching the site of pharmacological activity."

FDA adds that from a regulatory perspective, drugs designed to contain a new co-crystal are considered analogous to a new polymorph of the API.

“A co-crystal that is composed of two or more APIs (with or without additional inactive coformers) will be treated as a fixed-dose combination product and not a new API. If you are using a material that the Agency previously considered to be a co-crystal, you may continue to do so,” FDA says.

Ashwini Nangia becomes Director of CSIR-National Chemical Lab, Pune

posted Oct 19, 2009, 9:46 PM by Ashwini Nangia   [ updated Sep 8, 2016, 3:04 AM ]

University of Hyderabad Chemistry professor Ashwini Nangia on Wednesday 24th Feb, 2016 has been appointed as the Director of theCSIR-National Chemical Laboratory in Pune. CSIR-NCL is a science and knowledge based research, development and consulting organisation. 


It is internationally known for its excellence in scientific research in chemistry and chemical engineering as well as for its outstanding track record of industrial research involving partnerships with industry from concept to commercialization.


posted Oct 19, 2009, 9:44 PM by Ashwini Nangia   [ updated Sep 8, 2016, 3:06 AM ]

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